Invented at the Harvard Wyss Institute
Stata DX is based on the eRapid sensor technology developed at Harvard's Wyss Institute.
eRapid is a low-cost, affinity-based electrochemical sensing platform that can simultaneously detect a broad range of biomarkers with high sensitivity and selectivity in complex biological fluids, using as little as a single drop of blood.
It features a novel, antifouling nano-composite coating to which probes are attached that are specific to the target biomarker. When the target binds to the probe, it attracts a second probe to create a “sandwich” that triggers the formation of a local precipitate on the coated electrode surface that is electrically active.
The magnitude of the electrical signal generated correlates with the concentration of the target detected in the sample, and because the precipitate forms locally, many different biomarkers can be tested in parallel on the same sample.
Publications
Sabaté del Río, J., Henry, O.Y.F., Jolly, P., Ingber, D.E. An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids. Nature Nanotechnology 14, 1143–1149 (2019).
Zupančič, U., Jolly, P., Estrela, P., Moschou, D., Ingber, D.E. Graphene Enabled Low-Noise Surface Chemistry for Multiplexed Sepsis Biomarker Detection in Whole Blood. Adv. Funct. Mater. 2021, 31, 2010638.
Timilsina, S.S., Jolly, P., Durr, N., Yafia, M., Ingber, D.E. Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples. Accounts of Chemical Research 2021 54 (18), 3529-3539.
Timilsina, S.S., Durr, N., Yafia, M., Sallum, H., Jolly, P., Ingber, D.E. Ultrarapid Method for Coating Electrochemical Sensors with Antifouling Conductive Nanomaterials Enables Highly Sensitive Multiplexed Detection in Whole Blood. Adv. Healthcare Mater. 2022, 2102244.